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Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: Jun 4, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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WMDA guidelines for subsequent donations following initial BM or PBSCs.

D L Confer1, B E Shaw, D H Pamphilon

  • 1National Marrow Donor Program, Minneapolis, MN 55413, USA. dconfer@nmdp.org

Bone Marrow Transplantation
|February 8, 2011
PubMed
Summary

Subsequent stem cell donations from unrelated donors are increasing. While generally safe, donors should be informed about potential lower yields and counseled before initial donation.

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Area of Science:

  • Hematology
  • Transplantation immunology

Background:

  • Increasing activity in unrelated donor hematopoietic stem cell transplantation (SCT).
  • Potential need for subsequent stem cell or donor lymphocyte donations in 5-10% of cases.

Purpose of the Study:

  • To provide guidance on subsequent donations from unrelated stem cell donors.
  • To inform donors about the possibility and implications of repeat donations.

Main Methods:

  • Review of current practices and registry guidelines for subsequent donations.
  • Analysis of donor safety and stem cell yield in repeat donations.

Main Results:

  • Second stem cell donations do not increase donor complication risk.
  • Potential for reduced CD34+ cell yield in some repeat donors.
  • Subsequent donations are acceptable practice, requiring pre-donation counseling.

Conclusions:

  • Registries should counsel potential donors about the possibility of subsequent donations.
  • Clear guidelines are needed for medical assessment, request procedures, and donor follow-up for repeat donations.