Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induced Electric Fields: Applications

Induced Electric Fields: Applications

An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...

Electrochemical Gradient and Channel Proteins: An Overview

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Implantation of a passive electrical neurostimulation device achieves inflammatory modulation in rodents.

Communications biology·2026

Same author

Staged Versus Simultaneous Bilateral Deep Brain Stimulation: A Matched Comparison of Outcomes and Resource Utilization.

Neurosurgery·2026

Same author

Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease: A Nonrandomized Clinical Trial.

JAMA neurology·2025

Same author

Plasticity induced loss of apnea alarm through repeated apneas: A proposed mechanism for respiratory sudden death.

Epilepsy & behavior : E&B·2025

Same author

Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial.

NPJ Parkinson's disease·2024

Same author

Neuromuscular implants: Interfacing with skeletal muscle for improved clinical translation of prosthetic limbs.

Muscle & nerve·2023

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

A Galvanotaxis Assay for Analysis of Neural Precursor Cell Migration Kinetics in an Externally Applied Direct Current Electric Field

A Galvanotaxis Assay for Analysis of Neural Precursor Cell Migration Kinetics in an Externally Applied Direct Current Electric Field

Published on: October 13, 2012

Electrically mediated neuronal guidance with applied alternating current electric fields.

Matthew S Graves¹, Travis Hassell, Brooke L Beier

¹Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Annals of Biomedical Engineering

|February 8, 2011

Summary

High duty-cycle alternating current (AC) stimulation effectively generates electric fields (EFs) for neural recovery. This AC method shows promise for spinal cord repair, potentially outperforming direct current (DC) stimulation.

More Related Videos

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

Published on: February 16, 2012

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

Related Experiment Videos

Last Updated: Jun 4, 2026

A Galvanotaxis Assay for Analysis of Neural Precursor Cell Migration Kinetics in an Externally Applied Direct Current Electric Field

A Galvanotaxis Assay for Analysis of Neural Precursor Cell Migration Kinetics in an Externally Applied Direct Current Electric Field

Published on: October 13, 2012

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

Published on: February 16, 2012

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

Area of Science:

Neuroscience
Biomedical Engineering
Electrophysiology

Background:

Electric fields (EFs) are explored for neural trauma functional recovery.
Current research primarily uses direct current (DC) stimulation for neuronal growth.
Limitations of DC stimulation in EFs and power consumption exist.

Purpose of the Study:

To investigate high duty-cycle alternating current (AC) stimulation for neural repair.
To compare AC stimulation with DC stimulation for efficacy in spinal cord EFs and neurite growth.
To assess the potential benefits of AC stimulation, including field propagation and power efficiency.

Main Methods:

Ex vivo porcine spinal column tissue testing.
Xenopus laevis neuronal cell culture stimulation.
Comparison of 80% duty-cycle AC stimulation with DC stimulation.
Measurement of electric field generation and neurite outgrowth.

Main Results:

AC stimulation generated greater magnitude EFs over increased distances in spinal cords compared to DC.
80% duty-cycle AC stimulation significantly increased neurite length in neuronal cultures.
AC-stimulated neurite growth was statistically similar to DC-stimulated growth, with a cathodal preference.

Conclusions:

High duty-cycle AC stimulation is a viable alternative to DC stimulation for electrically mediated neuronal therapies.
AC stimulation offers potential advantages in field propagation and power consumption.
This modality may be preferable to DC stimulation for inducing functional recovery after neural trauma.