Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormones Regulating Blood Glucose

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are typically...

Hypoglycemia and Glucagon

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

Glucose Homeostasis: Regulation of Blood Glucose

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...

Oral Hypoglycemic Agents: Biguanides and Glitazones

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood glucose levels...

Oral Hypoglycemic Agents: Glinides

Oral Hypoglycemic Agents: Glinides

Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively manages...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: Where to Start in Ulcerative Colitis?

Alimentary pharmacology & therapeutics·2025

Same author

6-Thioguanine nucleotide levels are associated with infliximab but not adalimumab levels in inflammatory bowel disease patients on combination therapy.

Internal medicine journal·2024

Same author

Systematic review and meta-analysis of endoscopic versus medical management of peptic ulcers with adherent clots.

Journal of gastroenterology and hepatology·2024

Same author

Surveillance MRI is associated with improved survival in patients with primary sclerosing cholangitis.

Hepatology communications·2024

Same author

Editorial: improving the use of Montreal classification through a bidirectional approach.

Alimentary pharmacology & therapeutics·2023

Same author

Letter: diagnostic delay in inflammatory bowel disease.

Alimentary pharmacology & therapeutics·2023

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

A Model of Chronic Nutrient Infusion in the Rat

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Nutritional supplements and their effect on glucose control.

Tanya Lee¹, Jean-Jacques Dugoua

¹The Canadian College of Naturopathic Medicine, 400 Main Street East #210, Milton, ON, L9T 1P7, Canada. tanyalee.nd@gmail.com

Current Diabetes Reports

|February 8, 2011

Summary

Nutritional supplements like vitamins C and E may help manage type 2 diabetes. Always consult your doctor about potential interactions before starting any new supplement regimen.

More Related Videos

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jun 4, 2026

A Model of Chronic Nutrient Infusion in the Rat

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Area of Science:

Endocrinology
Nutritional Science
Pharmacology

Background:

Type 2 diabetes is a significant global health issue.
Nutritional supplement use among type 2 diabetes patients ranges widely (8-49%).

Purpose of the Study:

To review recent scientific literature on nutritional supplements for type 2 diabetes treatment and prevention.
To identify supplements with potential therapeutic benefits.

Main Methods:

Comprehensive search of twelve databases for studies published within the last three years.
Extraction and synthesis of data on supplement efficacy and safety.

Main Results:

Vitamins C and E, alpha-lipoic acid, melatonin, red mold, emodin, astragalus, and cassia cinnamon show potential benefits.
Beta-carotene was found ineffective for type 2 diabetes prevention.
Evidence spans preclinical to clinical studies.

Conclusions:

Nutritional supplements may play a role in type 2 diabetes management.
Further research is warranted to confirm efficacy and optimal usage.
Healthcare providers must assess drug-supplement interactions.