Related Experiment Video
Updated: Jun 4, 2026
Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis
Published on: March 11, 2017
Bone metabolism analyzed by PET and DXA following revision THA using a distally fixed stem. A pilot study
Gösta Ullmark1, Johan Kärrholm, Jens Sörensen
1Department of Orthopaedics, Gävle Hospital and Centre for Research & Development, Uppsala University/County Council of Gävleborg, Sweden. gosta.ullmark@lg.se
Abstract:
In a pilot study we analyzed bone remodeling using ¹⁸F-PET (positron emission tomography) scanning or DXA (dual-energy x-ray absorptiometry) in 3 patient groups, one with a loose femoral stem and 2 after revision using a modular stem (MP). In loose implants (group 1), bone formation activity compared to the contralateral healthy femur was 261 %. In the proximal part of the femur bone formation was increased by 253 % one week after revision (group 2) and did not normalize within 1 year. In the distal region it decreased to normal after one year. In the second revision group DXA showed decreased bone mineral density at 6 and 24 months (group 3). The PET technique provided evidence of bone healing despite osteolysis and prosthetic loosening which continued after revision. Decreasing BMD after revision in the third group is multifactorial, but suggests that despite intensive bone formation resorption was still higher.
