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The heptavalent pneumococcal conjugate vaccine immunization project by Bangkok Metropolitan in Thai infants

Wongwat Liulak1, Usa Thisyakorn

  • 1Communicable Disease Control Division, Health Department, Bangkok Metropolitan, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|February 8, 2011
PubMed

Insights

The heptavalent pneumococcal conjugate vaccine (PCV7) demonstrated safety and effectiveness in preventing invasive pneumococcal disease (IPD) in Thai infants. This study confirms PCV7

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Streptococcus pneumoniae is a leading cause of childhood bacteremia, sepsis, meningitis, pneumonia, sinusitis, and otitis media globally.
  • The heptavalent pneumococcal conjugate vaccine (PCV7) has shown high immunogenicity, safety, and efficacy against vaccine-contained serotypes in various studies.

Purpose of the Study:

  • To evaluate the safety and efficacy of the PCV7 vaccine when administered to infants in Thailand.
  • To assess the impact of PCV7 on the incidence of invasive pneumococcal disease (IPD) in the study population.

Main Methods:

  • A cohort of 97 infants received four doses of PCV7: three primary doses (2 months apart, starting at 2-6 months) and a booster dose (at 12-15 months).
  • Vaccine safety and reactogenicity were monitored through parental reports.
  • The occurrence of IPD among vaccinated infants was tracked for one year post-initial vaccination.

Main Results:

  • PCV7 was well-tolerated, with only two infants reporting mild fever.
  • No cases of invasive pneumococcal disease (IPD) were observed in any of the vaccine recipients during the study period.
  • The vaccine regimen proved to be safe for Thai infants.

Conclusions:

  • The administration of PCV7, including a primary series and a booster dose, appears to be a safe and effective strategy for preventing invasive pneumococcal disease (IPD) in Thai children.
  • These findings support the use of PCV7 in pediatric immunization programs in Thailand to reduce the burden of pneumococcal infections.
Abstract

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