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Related Concept Videos

Kepler's Third Law of Planetary Motion01:18

Kepler's Third Law of Planetary Motion

In the early 17th century, German astronomer and mathematician Johannes Kepler postulated three laws for the motion of planets in the solar system. In 1909, he formulated his first two laws based on the observations of his forebears, Nikolaus Copernicus and Tycho Brahe. However, in 1918, he published his third law of planetary motion, which gives a precise mathematical relationship between a planet's average distance from the Sun and the amount of time it takes to revolve around the Sun. It...
Kepler's First Law of Planetary Motion01:10

Kepler's First Law of Planetary Motion

In the early 17th century, German astronomer and mathematician Johannes Kepler postulated three laws for the motion of planets in the solar system. He formulated his first two laws based on the observations of his forebears, Nikolaus Copernicus and Tycho Brahe.
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Kepler's Second Law of Planetary Motion01:29

Kepler's Second Law of Planetary Motion

In the early 17th century, German astronomer and mathematician Johannes Kepler postulated three laws for the motion of planets in the solar system. His first law states that all planets orbit the Sun in an elliptical orbit, with the Sun at one of the ellipse's foci. Therefore, the distance of a planet from the Sun varies throughout its revolution around the Sun.
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Acceleration due to Gravity on Other Planets01:24

Acceleration due to Gravity on Other Planets

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Related Experiment Video

Updated: Jun 4, 2026

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

[JUPITER, what now?].

Gian Piero Perna1

  • 1Dipartimento di Scienze Cardiologiche Mediche e Chirurgiche, Struttura Complessa di Cardiologia G.M. Lancisi, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona. gp.perna@ao-umbertoprimo.marche.it

Giornale Italiano Di Cardiologia (2006)
|February 9, 2011
PubMed
Summary

The JUPITER study found that rosuvastatin significantly reduced cardiovascular events in healthy individuals with high high-sensitivity C-reactive protein (hsCRP). Treatment was most effective when LDL cholesterol and hsCRP levels were substantially lowered.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Pharmacology

Context:

  • The JUPITER trial investigated rosuvastatin in apparently healthy individuals with elevated high-sensitivity C-reactive protein (hsCRP) but without dyslipidemia.
  • This population typically falls outside standard lipid-lowering treatment guidelines.

Purpose:

  • To evaluate the efficacy of rosuvastatin in reducing cardiovascular events in a non-dyslipidemic population defined by elevated hsCRP.
  • To determine the impact of rosuvastatin on LDL cholesterol and hsCRP levels in this cohort.

Summary:

  • Administration of rosuvastatin (20 mg/day) resulted in a 55% decrease in LDL cholesterol and a 36% decrease in hsCRP.
  • A significant reduction in major cardiovascular events was observed, with maximal benefit seen when LDL cholesterol < 70 mg/dL and hsCRP < 2 mg/L.

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Last Updated: Jun 4, 2026

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

  • The study identified a specific patient profile (metabolic syndrome, family history of CVD) that particularly benefits from hsCRP measurement and rosuvastatin therapy.

    • Impact:

    • The findings support the "lower is better" hypothesis for LDL cholesterol and highlight hsCRP's role in identifying high-risk individuals among intermediate-risk groups.
    • Rosuvastatin is suggested as a highly effective statin with a favorable side-effect profile for selected patients.
    • The study has prompted significant discussion regarding the clinical application of hsCRP testing and statin therapy in primary prevention.