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Mouse Pneumonectomy Model of Compensatory Lung Growth
Published on: December 17, 2014
[Pneumonectomy in children]
Insights
Pneumonectomy in children offers good long-term survival and preserved respiratory function, with survivors enjoying unrestricted normal lives. This study reviews indications and sequelae in a pediatric cohort.
Area of Science:
- Pediatric surgery
- Thoracic surgery
- Pulmonary medicine
Context:
- Pneumonectomy (surgical removal of a lung) is rarely performed in children.
- Long-term outcomes following pediatric pneumonectomy are not well-documented.
Purpose:
- To retrospectively analyze the indications for pneumonectomy in children.
- To evaluate the long-term sequelae, including survival, pulmonary function, and quality of life, in a cohort of pediatric patients.
Summary:
- Ten pediatric patients underwent pneumonectomy for bronchiectasis, tumors, or congenital malformations.
- Overall survival was 90%, with all tumor patients cured and bronchiectasis patients showing improvement (except one with cystic fibrosis).
- Survivors exhibited well-preserved pulmonary function (FVC 58%, FEV1 60%) and reported unrestricted normal lives, with mild scoliosis in four cases.
Impact:
- Pneumonectomy in children, when indicated, does not adversely affect overall survival.
- Pediatric pneumonectomy can lead to good respiratory function and a high quality of life post-surgery.
- This study provides valuable data on the long-term effects of pneumonectomy in pediatric populations.
Background/Aim:
Pneumonectomy is seldom indicated in children and its long-term effects are not well known. The aim of the present study was to examine retrospectively the indications and the long-term sequelae in a relatively large cohort of patients treated at our institution.
Material And Methods:
We reviewed the charts of children undergoing pneumonectomy between 1969 and 2009 with particular attention to indications, techniques, complications, survival, pulmonary function and spine deformities
Results:
Ten patients (M:F=6/4) aged 102 +/- 66 months underwent pneumonectomy for bronchiectasis (4, one with cystic fibrosis), tumors (4, 1 myofibroblastic inflammatory pseudotumor, 1 bronchial carcinoid, 1 primary pulmonary PNET and 1 massive metastasis of osteosarcoma) and malformations (2, 1 pulmonary sequestration and 1 congenital bilobar emphysema). Overall survival was 90% at 5.6 (0.3-23) years. Patients with bronchiectasis improved markedly except the one with cystic fibrosis who died. All children with tumors cured. Four have some degree of scoliosis which is severe in one with malformative costal fusion. All survivors live unrestristricted normal lives. Postoperative respiratory function is well preserved with FVC of 58% (40-70%), FEV1 of 60% (47-84%) and FEV1/FVC of 92% (87-98%) of the theoretical value for their height and weight.
Conclusions:
Pneumonectomy does not affect by itself to the overall survival, and the respiratory function is good and there is no impairment of the quality of life.
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