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Updated: Jun 4, 2026
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
[Bladder malformations in a model of myelomeningocele. Preliminary report]
J L Encinas1, M Germani, L Burgos
1Departamento de Cirugía Pediátrica, Hospital La Paz, Madrid.
Purpose:
To describe the presence of bladder malformations in a surgically induced model of myelomeningocele (MMC).
Methods:
A MMC like defect was created in the mid gestation using the previously described model in sheep. Bladders were examined macroscopically and histopathological changes were assessed using H-E.
Results:
Non prenatally corrected animals presented dilated bladders and separation between muscle bundles. Those malformations were not found in corrected animals or controls.
Conclusions:
Some bladder changes can be described in a surgically-induced model of MMC. These changes could be prevented using open fetal surgery.
