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Mitral deceleration index is associated with aortic root dilatation and not to biventricular structural changes in

Cesare Cuspidi1, Francesca Negri, Carla Sala

  • 1Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Italy. cesare.cuspidi@unimib.it

Blood Pressure
|February 9, 2011
PubMed

Insights

The mitral deceleration index (MDI) in hypertension is not linked to structural heart changes but is associated with aortic root dilation, a cardiovascular risk factor.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • The mitral deceleration index (MDI) shows promise in predicting cardiovascular events in hypertension.
  • Limited data exists on the relationship between MDI and cardiac structure.

Purpose of the Study:

  • To investigate the association between MDI and cardiac structural parameters in essential hypertensives.
  • To compare MDI with deceleration time alone in assessing cardiac structure.

Main Methods:

  • Analysis of 329 hypertensive subjects categorized into MDI tertiles.
  • Comprehensive echocardiography for left and right heart chamber assessment.
  • Multivariate analysis adjusting for covariates.

Main Results:

  • Aortic root diameter was significantly associated with MDI after adjustments.
  • MDI was independently associated with age and aortic root diameter.
  • No significant association found between MDI and left ventricular or right ventricular structural parameters.

Conclusions:

  • MDI is unrelated to left and right ventricular structural changes in hypertension.
  • Altered diastolic function, indicated by MDI, is linked to aortic root dilation.
  • Aortic root dilation is a predictor of cardiovascular morbidity and mortality.

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