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Evaluation of the Health Utilities Index Mark-3 in heart failure

Susan J Pressler1, George J Eckert, Gwendolyn C Morrison

  • 1The University of Michigan School of Nursing, 400 N. Ingalls, Ann Arbor, MI 48109, USA. spressle@umich.edu

Journal of Cardiac Failure
|February 9, 2011
PubMed

Insights

The Health Utilities Index Mark-3 (HUI-3) shows adequate reliability and validity for heart failure cost-effectiveness studies, despite some limitations in responsiveness and internal consistency.

Area of Science:

  • Health Economics
  • Quality of Life Measurement
  • Cardiology

Background:

  • Heart failure (HF) significantly impacts patients' quality of life.
  • Cost-effectiveness studies require validated instruments to assess health utilities.

Purpose of the Study:

  • To evaluate the Health Utilities Index Mark-3 (HUI-3) for reliability, validity, and responsiveness in heart failure patients.
  • To determine the suitability of the HUI-3 for cost-effectiveness analyses in HF.

Main Methods:

  • 211 HF patients were enrolled; 165 completed a 26-week study.
  • Health-related quality of life was assessed using HUI-3, SF-12, LHFQ, and CHQ at multiple time points.
  • Reliability (internal consistency, test-retest) and validity (associations with other QoL measures, discrimination by NYHA class) were analyzed.

Main Results:

  • HUI-3 indicated moderate/fair quality of life, with pain, ambulation, cognition, and emotion most affected.
  • Internal consistency reliability was low (Cronbach's alpha = 0.51), but test-retest reliability was adequate (ICC = 0.68).
  • HUI-3 scores correlated with SF-12, LHFQ, and CHQ, and discriminated by NYHA class and perceived health, but showed lower responsiveness than LHFQ/CHQ.

Conclusions:

  • The HUI-3 demonstrated satisfactory reliability and validity in this heart failure cohort.
  • These findings support the HUI-3's use in cost-effectiveness studies for heart failure.
  • Consideration of HUI-3's limitations in responsiveness and internal consistency is warranted.
Abstract

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