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Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...

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Related Experiment Video

Updated: Jun 4, 2026

Toxin Induction and Protein Extraction from Fusarium spp. Cultures for Proteomic Studies

Toxin Induction and Protein Extraction from Fusarium spp. Cultures for Proteomic Studies

Published on: February 16, 2010

FunSecKB: the Fungal Secretome KnowledgeBase.

Gengkon Lum¹, Xiang Jia Min

¹Department of Computer Science and Information Systems, Center for Applied Chemical Biology, Youngstown State University, Youngstown, OH 44555, USA.

Database : the Journal of Biological Databases and Curation

|February 9, 2011

Summary

The Fungal Secretome KnowledgeBase (FunSecKB) is a new database detailing fungal secreted proteins (secretomes). It aids research into fungal secreted proteins and their applications using computational tools and community annotation.

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Area of Science:

Mycology
Proteomics
Bioinformatics

Background:

Fungal secretomes are crucial for understanding fungal biology and interactions.
Existing resources may lack comprehensive data or user-friendly access to fungal secreted proteins.

Purpose of the Study:

To develop and present the Fungal Secretome KnowledgeBase (FunSecKB) as a centralized resource.
To facilitate the exploration and study of fungal secreted proteins and their potential applications.

Main Methods:

Utilized computational tools (SignalP, WolfPsort, Phobius, TMHMM, PS-Scan) for secreted protein identification.
Integrated data from NCBI RefSeq and mapped entries to UniProt.
Developed a web-based interface for searching, browsing, and downloading data.

Main Results:

Successfully identified and cataloged fungal secreted proteins from the NCBI RefSeq database.
Included manually curated and computationally predicted subcellular location annotations.
Implemented functionalities for BLAST searches and community-driven annotation.

Conclusions:

FunSecKB provides a valuable, comprehensive resource for fungal secretome research.
The database supports diverse research avenues, from basic biology to applied mycology.
Community involvement through user submissions enhances the database's utility and accuracy.