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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Generation and Manipulation of Rat Intestinal Organoids
09:49

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Published on: June 23, 2023

Differences in rat models used in routine toxicity studies.

Klaus Weber1, Tanja Razinger, Jerry F Hardisty

  • 1AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland. kweber@harlan.com

International Journal of Toxicology
|February 9, 2011
PubMed
Summary
This summary is machine-generated.

Choosing the right rat model, such as Sprague Dawley (SD) or Fischer F344, is crucial for rodent toxicity studies. Understanding historical data on survival and neoplasms ensures accurate oncogenicity study outcomes.

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Area of Science:

  • Toxicology
  • Rodent Models
  • Preclinical Research

Background:

  • Ongoing debate regarding the optimal rat strain for toxicity studies.
  • Availability of extensive historical data on Sprague Dawley (SD), Fischer F344, and Hannover Wistar rats.
  • Oncogenicity studies are a standard requirement for compounds in development.

Purpose of the Study:

  • To highlight the importance of selecting an appropriate rat model for toxicity studies.
  • To emphasize the need for understanding historical background data for chosen rat strains.
  • To guide researchers in making informed decisions at the outset of toxicology programs.

Main Methods:

  • Review of published data on Sprague Dawley (SD), Fischer F344, and Hannover Wistar rat strains.
  • Analysis of factors influencing rat model selection for toxicity testing.
  • Consideration of historical data on survival, body weight, and lesion incidence.

Main Results:

  • Rat model selection impacts oncogenicity study outcomes.
  • Historical data on survival, neoplasms, and age-dependent lesions are critical.
  • Strain-specific characteristics necessitate careful consideration in study design.

Conclusions:

  • The choice of rat model (e.g., Sprague Dawley, Fischer F344, Wistar) significantly influences toxicity study results.
  • Thorough understanding of historical strain data is essential for accurate interpretation of oncogenicity and other toxicity endpoints.
  • Strategic selection of rat models at the program's inception is vital for successful preclinical development.