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[A comparison of the child's behavior between two groups of oral sedative drugs]
1Faculty of Dentistry, Mahidol University, Bangkok.
Insights
Hydroxyzine and Diazepam demonstrated superior outcomes in managing child behavior during dental procedures compared to Chloral hydrate and Promethazine, significantly reducing crying and movement.
Area of Science:
- Pediatric Dentistry
- Pharmacology
- Behavioral Science
Background:
- Managing negative behavior in children during dental restorative appointments is crucial.
- Oral sedative drugs combined with nitrous oxide-oxygen inhalation are often used for anxious children.
Purpose of the Study:
- To compare the efficacy of two oral sedative drug combinations in managing child behavior during dental procedures.
- Specifically, to evaluate Chloral hydrate and Promethazine versus Hydroxyzine and Diazepam.
Main Methods:
- A double-blind study involving 14 healthy children aged 3-5 years with negative dental behavior.
- Randomized administration of either Chloral hydrate/Promethazine or Hydroxyzine/Diazepam.
- Evaluation of sleep, crying, movement, and overall behavior during treatment.
Main Results:
- No significant difference in sleep levels between the two drug groups.
- Hydroxyzine and Diazepam significantly reduced crying and movement compared to Chloral hydrate and Promethazine.
- Overall behavior was significantly better with Hydroxyzine and Diazepam.
Conclusions:
- Hydroxyzine and Diazepam offer a more effective sedation option for managing behavior in young children undergoing dental treatment.
- This combination may be preferred over Chloral hydrate and Promethazine for reducing distress and improving cooperation.
Abstract:
The purpose of this study was to compare the child's behavior between the two groups of oral sedative drugs: a) Chloral hydrate and Promethazine and b) Hydroxyzine and Diazepam. Fourteen healthy children, aged 3 to 5 years old, participated in this study. All children exhibited negative behavior and required at least two restorative appointments with the use of oral sedative drugs and nitrous oxide-oxygen inhalation sedation. The drugs were randomly administered in a double-blind manner. The degree of sleep, crying, movement and overall behavior were evaluated during the operative procedures. With respect to sleeping, there was no significant difference in the child's behavior between the two drug groups. With respect to crying, the children who had Hydroxyzine and Diazepam cried significantly less than when they had Chloral hydrate and Promethazine at the time of injection and rubber dam placement (P less than 0.05). With respect to movement, the children who had Hydroxyzine and Diazepam moved significantly less than when they had Chloral hydrate and Promethazine at the time of injection, rubber dam placement, and the 60 minute interval (P less than 0.05). For overall behavior, the children who had Hydroxyzine and Diazepam behaved better than when they had Chloral hydrate and Promethazine (P less than 0.05).