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Published on: September 20, 2021
Benzimidazole analogs inhibit human herpesvirus 6
Mark N Prichard1, Samuel L Frederick, Shannon Daily
1University of Alabama School of Medicine, 1600 6th Avenue South, 128 Children's Harbor Building, Birmingham, AL 35233, USA. mprichard@peds.uab.edu
None:
Several benzimidazole nucleoside analogs, including 1H-β-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two L-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.
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