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ASA-Induced Hypoprothrombinemia: A Case Report.

Canadian Family Physician Medecin De Famille Canadien

|February 9, 2011

Summary

This summary is machine-generated.

Aspirin (ASA) can rarely cause prolonged prothrombin time and gastrointestinal bleeding, especially in elderly patients with a history of ulcers. Vitamin K effectively reverses this condition, stopping the bleeding.

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Area of Science:

Internal Medicine
Gastroenterology
Pharmacology

Background:

Gastrointestinal (GI) bleeding is a serious complication in elderly patients, particularly after surgery.
Aspirin (ASA) is commonly used for pain and inflammation but can affect coagulation.
Elderly patients, especially those with a history of peptic ulcer disease, are at increased risk for GI complications.

Purpose of the Study:

To report a rare case of hypoprothrombinemia and GI bleeding caused by aspirin therapy.
To highlight the importance of considering aspirin-induced hypoprothrombinemia in patients with unexplained bleeding.
To demonstrate the efficacy of Vitamin K in reversing aspirin-induced coagulation abnormalities.

Main Methods:

A case study of an elderly male patient who developed GI bleeding and prolonged prothrombin time.
Review of the patient's medication history, focusing on aspirin (ASA) use.
Administration of Vitamin K and monitoring of prothrombin time and bleeding status.

Main Results:

The patient experienced a GI bleed and prolonged prothrombin time after 19 days of ASA therapy.
Prothrombin time normalized within 24 hours of Vitamin K administration.
Bleeding ceased and did not recur, with no specific bleeding site identified.

Conclusions:

Aspirin (ASA) can induce hypoprothrombinemia, a rare but reversible cause of GI bleeding.
Vitamin K is an effective antidote for aspirin-induced hypoprothrombinemia.
Clinical vigilance is necessary to identify and manage this adverse effect of aspirin therapy, especially in at-risk populations.