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Updated: Jun 4, 2026
08:21
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
Published on: June 15, 2020
Left ventricular dysfunction due to right ventricular stimulation: is biventricular upgrade really necessary?
T den Besten1, M I Sedney, J Frederiks
1Department of Cardiology, Bronovo Hospital, The Hague, the Netherlands.
Summary
Reprogramming atrioventricular (AV) timing can reverse left ventricular (LV) dysfunction caused by right ventricular pacing. Optimizing AV timing may avoid unnecessary pacemaker upgrades, improving cardiac function.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Medical Device Technology
Background:
- Chronic right ventricular apical pacing can lead to left ventricular (LV) dysfunction.
- Pacemaker upgrades to biventricular pacing are a known intervention for LV dysfunction.
- Atrioventricular (AV) timing reprogramming is an alternative consideration.
Purpose of the Study:
- To describe the impact of AV-time reprogramming on LV function in a patient with pacing-induced dysfunction.
- To evaluate the efficacy of AV timing optimization as a conservative measure.
Main Methods:
- Case report detailing a patient with sick sinus syndrome and subsequent LV dysfunction.
- Utilized echocardiography to assess LV function over a two-year follow-up period.
- Monitored right ventricular pacing percentage and AV timing parameters.
Main Results:
- Significant improvement in left ventricular function observed during follow-up.
- Dramatic reduction in the percentage of right ventricular pacing occurred.
- AV-time reprogramming was associated with improved cardiac mechanics.
Conclusions:
- Careful analysis of LV dysfunction causes is crucial.
- Optimizing AV timing can be an effective strategy to improve LV function.
- This approach may prevent the need for costly pacemaker upgrades to biventricular systems.
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