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Related Experiment Video

Updated: Jun 4, 2026

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
09:00

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

Water: a simple solution for tumor spillage.

Fumito Ito1, Marta Camoriano, Mukund Seshadri

  • 1Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Annals of Surgical Oncology
|February 9, 2011
PubMed
Summary

Water lavage effectively reduces tumor burden and improves survival following tumor spill during surgery. This method offers a safe and cost-effective approach to minimize peritoneal disease progression in oncologic procedures.

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Area of Science:

  • Oncology
  • Surgical Innovation
  • Cancer Research

Background:

  • Tumor spill during surgery can lead to disease recurrence.
  • Water lavage is proposed to mitigate these consequences.
  • Systematic evaluation in preclinical models is lacking.

Purpose of the Study:

  • To evaluate the mechanisms and efficacy of water lavage in reducing tumor spill sequelae.
  • To compare water lavage with saline lavage and sham laparotomy.
  • To assess the impact on tumor burden and survival.

Main Methods:

  • In vitro assessment of murine colorectal cancer cell lysis by water.
  • Establishment of a murine model for tumor spill during laparotomy.
  • Comparison of water lavage, saline lavage, and sham laparotomy outcomes via imaging and survival analysis.

Main Results:

  • Water induced significant osmotic lysis of cancer cells in vitro.
  • Water lavage resulted in decreased tumor volumes compared to saline or sham procedures.
  • Improved survival rates were observed in mice treated with water lavage.

Conclusions:

  • Water lavage is a justified and effective method to reduce tumor spill consequences during oncologic surgery.
  • Concerns exist regarding the efficacy and mechanisms of saline lavage.
  • Water lavage offers a low-toxicity, low-cost clinical strategy to reduce peritoneal disease burden.