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Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

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Related Experiment Video

Updated: Jun 4, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

An Ly-like specificity with extensive nonlymphoid expression.

P F Halloran1, D Dutton, H Chance

  • 1Department of Medicine, Mt. Sinai Hospital, 600 University Ave., M5G 1X5, Toronto, Canada.

Immunogenetics
|February 9, 2011
PubMed
Summary
This summary is machine-generated.

A novel mouse alloantigen, likely Ly-6.2, shows strong expression in kidneys and lymphoid tissues. Its genetic control and broad tissue distribution suggest potential histocompatibility effects in transplantation.

Related Experiment Videos

Last Updated: Jun 4, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Area of Science:

  • Immunology
  • Genetics
  • Transplantation Biology

Background:

  • Characterization of mouse alloantigens is crucial for understanding immune responses and transplantation.
  • The Ly-6 alloantigen system is a known marker on lymphocytes, but its broader expression patterns require further investigation.

Purpose of the Study:

  • To characterize a strong mouse alloantigen with significant expression in renal, bone marrow, and lymphoid tissues.
  • To determine the genetic control and cellular distribution of this antigen, likely Ly-6.2.
  • To explore the potential histocompatibility implications of this broadly expressed alloantigen.

Main Methods:

  • Utilized high-titered cytotoxic antisera to define the alloantigen's specificity against various mouse strains.
  • Employed genetic analysis (F(2) and backcross generations) to determine the mode of inheritance.
  • Performed sequential absorption studies and compared antigen expression levels with H-2 antigens in kidney tissue.
  • Assessed antigen presence on T cells, B cells, bone marrow cells, and a nonlymphoid tumor (P815Y mastocytoma).

Main Results:

  • The alloantigen, likely Ly-6.2, demonstrated potent cytotoxic activity across multiple mouse strains.
  • Genetic analysis revealed single autosomal dominant gene control.
  • Significant expression was observed in lymphoid tissues (predominantly T cells, some B cells) and strongly in kidney tissue, comparable to H-2 antigen levels.
  • Bone marrow cells (40-50%) and the P815Y mastocytoma also expressed the antigen, indicating extensive nonlymphoid distribution.

Conclusions:

  • The studied alloantigen, identified as likely Ly-6.2, exhibits broad tissue expression beyond lymphocytes, including kidney and tumor cells.
  • The extensive expression and antigenic strength suggest Ly-6.2 may play a role in histocompatibility and influence allograft outcomes.
  • Further studies are warranted to examine the histocompatibility effects of Ly-6.2 in tissue transplantation.