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Immunoglobulin isoantigens (allotypes) in the mouse : V. Characterization of IgM allotypes

S J Black1, J W Goding, G A Gutman

  • 1Department of Genetics, Stanford University School of Medicine, 94305, Stanford, California.

Immunogenetics
|February 9, 2011
PubMed

Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound μ chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.

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