Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 4, 2026

The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Matrix techniques applied to CML-typedH-2 mutants.

A Wohlgemuth1

  • 1Department of Mathematics, University of Maine at Orono, 04473, Orono, Maine.

Immunogenetics
|February 9, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A fragment-cofragment model of antibody incidence structures.

Mathematical biosciences·2011
Same author

Defining specificities, genes, antigens, and antibodies- A matrix approach.

Immunogenetics·2011
Same author

Serological interpretation--theoretical limits to information from blocking.

Mathematical biosciences·1990
Same author

Symbolic reinterpretation of HLA gene products--impact on interpretation of HLA data at the molecular level.

Computer applications in the biosciences : CABIOS·1987
Same author

The impact of symbolism on immunogenetics: an application to HLA.

Journal of theoretical biology·1987
Same author

An interactive program for determining tentative gene assignments from immunological data.

Computers and biomedical research, an international journal·1987
Same journal

Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in Bubalus bubalis and Ovis aries.

Immunogenetics·2026
Same journal

Genetic characterization of the TAPBP and its allelic association with BF2 in the chicken major histocompatibility complex.

Immunogenetics·2026
Same journal

Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1-CH2, an intermediate CH3, and an IgM-like CH4.

Immunogenetics·2026
Same journal

Climate factors and selection shape MHC class II diversity in a montane wild sheep (Ovis ammon).

Immunogenetics·2026
Same journal

Deciphering APOBEC1 in Avians: unravelling loss events and functional insights.

Immunogenetics·2026
Same journal

Allelic diversity and selection at the MHC class I and class II in a long-distance migratory shorebird, the Hudsonian Godwit (Limosa haemastica).

Immunogenetics·2026
See all related articles

The Labeled Reaction Matrix model assigns discrete labels to H-2 haplotypes, improving the interpretation of weak serological reactions. This method enhances decision-making for positive or negative reaction assignments, guiding future research.

Area of Science:

  • Immunogenetics
  • Computational Biology
  • Serology

Background:

  • Serological typing of H-2 haplotypes is crucial for understanding immune responses.
  • Interpreting reactions of questionable strength can be challenging.
  • The H-2 complex plays a vital role in the murine immune system.

Purpose of the Study:

  • To apply the Labeled Reaction Matrix model for discrete labeling of H-2 haplotypes.
  • To demonstrate how model internal consistency aids in classifying weak serological reactions.
  • To derive labeling schemes for further experimental investigation.

Main Methods:

  • Utilized techniques from the Labeled Reaction Matrix model.
  • Assigned discrete labels to serologically identical, CML-typed H-2 haplotypes.

More Related Videos

Isolating Interaction-Null/Impaired Mutants Using the Yeast Two-Hybrid Assay
02:44

Isolating Interaction-Null/Impaired Mutants Using the Yeast Two-Hybrid Assay

Published on: December 29, 2023

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

Related Experiment Videos

Last Updated: Jun 4, 2026

The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Isolating Interaction-Null/Impaired Mutants Using the Yeast Two-Hybrid Assay
02:44

Isolating Interaction-Null/Impaired Mutants Using the Yeast Two-Hybrid Assay

Published on: December 29, 2023

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

  • Employed internal consistency checks for decision-making on reaction strength.

    • Main Results:

    • Successfully assigned discrete labels to specific H-2 haplotypes.
    • Showcased the model's utility in resolving ambiguous reaction strengths.
    • Generated novel labeling schemes for potential experimental validation.

    Conclusions:

    • The Labeled Reaction Matrix model provides a robust framework for H-2 haplotype classification.
    • Internal consistency analysis is effective for interpreting borderline serological data.
    • Derived labeling schemes offer new avenues for immunogenetic research.