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Expression of Ly-6 on activated T and B cells: Possible identity with Ala-1

A J Feeney1

  • 1Department of Biology, University of California, 92093, San Diego, La Jolla, California.

Immunogenetics
|February 9, 2011
PubMed

The antigens Ala-1 and Ly-6 were first thought to be different on the grounds that Ala-1 was present only on activated T and B lymphocytes while Ly-6 was present only on post-thymic T lymphocytes. In this paper, it is shown that Ly-6 is expressed on activated B cells, including PFC and LPS blasts, and that after typing of several recombinant inbred lines,Ala-1 andLy-6 remain genetically inseparable. Based on available data, it is most likely that Ly-6 is in fact Ala-1, although further testing is required to confirm the absence of Ly-6 from nonactivated lymphocytes.

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