[Epileptic seizures: effects on cardiac function]
L Burghaus1, G R Fink, E Erdmann
1Klinik und Poliklinik für Neurologie, Uniklinik Köln, Köln. lothar.burghaus@uk-koeln.de
Insights
Sudden loss of consciousness requires both cardiac and neurological evaluation. This review details cardiac effects of epileptic seizures and explores potential links between heart and brain channelopathies.
Area of Science:
- Neurology
- Cardiology
- Channelopathies
Context:
- Sudden loss of consciousness is a common clinical presentation.
- Distinguishing syncope from epileptic seizures necessitates integrated cardiologic and neurologic assessments.
- Epilepsy research highlights sudden unexpected death in epilepsy (SUDEP) and its association with cardiac events.
Purpose:
- To review the cardiac manifestations of epileptic seizures.
- To explore the potential pathogenetic correlations between cardiac and epileptic channelopathies.
- To emphasize the clinical relevance of interdisciplinary collaboration between cardiology and neurology.
Summary:
- Epileptic seizures can precipitate cardiac arrhythmias and asystole.
- Cardiac channelopathies, like long QT syndrome, may co-occur with seizures.
- A potential link exists between cardiac and cerebral channelopathies.
Impact:
- This review underscores the importance of considering cardiac involvement in epilepsy.
- It highlights the need for collaborative diagnostic and therapeutic strategies.
- Understanding the interplay between cardiac and neurological channelopathies may improve patient outcomes and inform SUDEP research.
Abstract:
Sudden loss of consciousness can be caused by syncope or epileptic seizure, which therefore requires a diagnostic work-up including cardiological and neurological examinations. Thus, in clinical practice cooperation of these two medical specialties is common and of high relevance. Seizures may lead to cardiac arrhythmia or ictal asystole, and "sudden unexpected death in epilepsy" (SUDEP) is an important field of epilepsy research. Cardiac channelopathies such as long QT syndrome may be associated with seizures, suggesting a possible link between cardiac and cerebral channelopathy. We here review in detail cardiac effects due to epileptic seizures as well as possible pathogenetic correlations between cardiac and epileptic diseases.
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