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Updated: Jun 4, 2026
Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
Published on: September 7, 2022
[Preparation of zoledronic-acid-loaded collagen membrane]
Yan-hua Meng1, Xing Liang, Yan Peng
1State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Objective:
To develop a new local delivery system, osteoclastic-inhibitor-loaded collagen membrane, and to evaluate its drug loading and drug release properties.
Methods:
Efforts were made to develop the drug-loaded membranes by combining two commercially available collagen barrier membranes (Bio-Gide and BME-10X) with zoledronic acid (ZA). The physicochemical and pharmacological properties of resulting materials were determined using SEM, EDS, FTIR, and HPLC.
Results:
After ZA loading, the micropores between the thin collagen fibers in the Bio-Gide disappeared, whereas crystalloid powders appeared on the surface of pore walls in BME-10X. Phosphorus was detected on both drug-loaded membranes. The Amides shifted. With the same drug solution, Bio-Gide presented larger amount of ZA loading and slower ZA release than BME-10X. ZA loading did not affect the 3D fiber network and the degradation of membranes.
Conclusion:
Both collagen membranes load ZA successfully and delay drug release. But Bio-Gide shows higher loading values and slower release than BME-10X.
