Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocrine-related osteoporosis: the state of the art.

Frontiers in endocrinology·2026
Same author

Beyond the Genome: Can Epigenetics Forecast Therapeutic Success in Graves' Disease and Thyroid Eye Disease?

International journal of molecular sciences·2026
Same author

Micro-costing analysis from Italian Guidelines for the management of sporadic primary hyperparathyroidism.

Global & regional health technology assessment·2025
Same author

Phosphate metabolism in primary hyperparathyroidism: a real-life long-term study.

Endocrine·2025
Same author

Molecular Pathophysiology of Parathyroid Tumorigenesis-The Lesson from a Rare Disease: The "MEN1 Model".

International journal of molecular sciences·2024
Same author

Glycogen Storage Disease Type I and Bone: Clinical and Cellular Characterization.

Calcified tissue international·2024
Same journal

End-of-life decisions and opinions: Results of E.L.D.Y.-CA.RE study carried out at Veneto Institute of Oncology, Italy.

Tumori·2026
Same journal

Quality indicators in identification and care of patients with genetic predisposition to cancer: An AIFET proposal.

Tumori·2026
Same journal

Driver vs. passenger: Primary resistance to larotrectinib in synovial sarcoma harboring concurrent SS18 rearrangement and PDE3A-NTRK2 fusion.

Tumori·2026
Same journal

Beyond the calendar: A narrative review on chronobiological drivers of prognosis in resectable NSCLC.

Tumori·2026
Same journal

Challenging the cornerstone: Toward risk-adapted follow-up in early breast cancer.

Tumori·2026
Same journal

Assessing in house comprehensive genomic profiling by liquid biopsy for NSCLC patients.

Tumori·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

MEN syndromes.

Alberto Falchetti1

  • 1Department of Internal Medicine, University of Florence and Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Florence, Italy.

Tumori
|February 10, 2011
PubMed
Summary
This summary is machine-generated.

Multiple Endocrine Neoplasia (MEN) syndromes are inherited cancers. Genetic testing enables early detection and intervention, significantly reducing mortality and morbidity associated with these rare conditions.

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Related Experiment Videos

Last Updated: Jun 4, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Multiple Endocrine Neoplasia (MEN) types 1 and 2 are rare inherited cancer syndromes.
  • These syndromes are characterized by a predisposition to various endocrine and nonendocrine tumors.
  • Advances in understanding MEN pathophysiology have improved patient outcomes.

Purpose of the Study:

  • To highlight the role of genetic testing in the early detection of MEN syndromes.
  • To emphasize the impact of early and tailored interventions on disease course.
  • To discuss the reduction in mortality and morbidity for MEN-associated tumors.

Main Methods:

  • Review of current knowledge on MEN syndromes.
  • Analysis of the impact of genetic testing availability.
  • Evaluation of early detection and intervention strategies.

Main Results:

  • Genetic testing is crucial for identifying asymptomatic carriers of MEN-associated mutations.
  • Early detection and intervention lead to reduced mortality and morbidity.
  • Tailored interventions positively impact the clinical course of MEN syndromes.

Conclusions:

  • Improved understanding and genetic testing have transformed MEN syndrome management.
  • Genetic testing plays a pivotal role in proactive healthcare for hereditary cancer syndromes.
  • Early diagnosis and intervention are key to improving survival and quality of life for MEN patients.