Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Aneurysm IV: Nursing Management

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...

General Anesthesia: Overview

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Successful management of a thoracoabdominal impalement injury.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2024

Same author

Profile of Pediatric Trauma among the Patients Attending Emergency Department in a Tertiary Care Hospital in South India.

Journal of emergencies, trauma, and shock·2020

Same author

Clinical Profile and Autopsy Findings in Fatal Head Injuries.

Journal of emergencies, trauma, and shock·2018

Same author

One man's wars.

Journal of the Royal Army Medical Corps·2018

Same author

Pediatric Trauma - An Emerging Epidemic.

Indian pediatrics·2018

Same author

A History of Intravenous Anesthesia in War (1656-1988).

Journal of anesthesia history·2016

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

Total intravenous anaesthesia for war surgery.

S Lewis¹, S Jagdish

¹St. George's Healthcare NHS Trust, London. drselewis@googlemail.com

Journal of the Royal Army Medical Corps

|February 10, 2011

Summary

Total intravenous anaesthesia (TIVA) and target-controlled infusion (TCI) offer clinical benefits and logistical advantages. Advances in pharmacokinetics enable precise anesthesia titration, useful in diverse settings, including combat trauma.

Area of Science:

Anesthesiology
Pharmacokinetics
Pharmacodynamics

Background:

Total intravenous anaesthesia (TIVA) and target-controlled infusion (TCI) leverage modern technology for anesthesia delivery.
These techniques offer significant clinical and logistical advantages over traditional methods.

Purpose of the Study:

To highlight the benefits and applications of TIVA and TCI.
To emphasize the role of pharmacokinetic and pharmacodynamic understanding in optimizing anesthetic management.
To underscore the need for continued research in complex patient populations.

Main Methods:

Review of advancements in microprocessor technology and anesthetic drug design.
Application of population pharmacokinetic data for drug handling models.

More Related Videos

Non-Intubated Video-Assisted Thoracoscopic Surgery

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jun 4, 2026

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

Non-Intubated Video-Assisted Thoracoscopic Surgery

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Individual patient titration of anesthesia based on pharmacokinetic principles.

Main Results:

TIVA and TCI enable precise anesthesia titration, improving patient management.
These methods provide valuable alternatives in both austere and deployed environments.
Understanding drug handling is crucial for effective intravenous anesthesia.

Conclusions:

TIVA and TCI are valuable anesthetic techniques supported by technological and pharmacokinetic advancements.
These approaches offer flexibility and efficacy in various clinical settings.
Further research into the pharmacokinetics and pharmacodynamics of anesthetic agents in combat trauma patients is essential.