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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Updated: Jun 4, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

The paediatric transfusion challenge on deployed operations.

S Bree1, K Wood, G R Nordmann

  • 1MDHU Derriford, Plymouth. stephen.bree@phnt.swest.nhs.uk

Journal of the Royal Army Medical Corps
|February 10, 2011
PubMed
Summary
This summary is machine-generated.

This guide addresses massive transfusion protocols for severely injured children, offering management strategies for military anaesthetists. It aims to fill a gap in UK paediatric trauma guidelines.

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Last Updated: Jun 4, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Pediatric Trauma Surgery
  • Massive Transfusion Protocols
  • Military Medicine

Background:

  • Severely injured children often require massive transfusions, posing significant clinical challenges.
  • Existing UK guidelines for massive transfusion in paediatric trauma are lacking, particularly in deployed settings.
  • Specialist centres possess protocols for elective paediatric surgery but not general trauma.

Purpose of the Study:

  • To provide a management guide for massive transfusion in severely injured paediatric patients.
  • To adapt existing operational policies for use by military anaesthetists in trauma scenarios.
  • To address the absence of specific UK paediatric trauma massive transfusion guidelines.

Main Methods:

  • Development of a management guide based on the Surgeon General's Operational Policy Letter.
  • Review of current practices in specialist UK centres for paediatric massive transfusion during surgery.
  • Adaptation of guidelines for military anaesthetists managing paediatric trauma.

Main Results:

  • A practical guide for managing massive transfusion in severely injured children has been produced.
  • The guide is tailored for military anaesthetists facing complex paediatric trauma cases.
  • It bridges the gap in UK-specific paediatric trauma massive transfusion protocols.

Conclusions:

  • The developed guidelines offer crucial support for managing paediatric massive transfusion in trauma.
  • Military anaesthetists can utilize this guide for challenging paediatric cases encountered in deployed environments.
  • This initiative aims to standardize care and improve outcomes for critically injured children.