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Target tracking using DMLC for volumetric modulated arc therapy: a simulation study.

Baozhou Sun1, Dharanipathy Rangaraj, Lech Papiez

  • 1Department of Radiation Oncology, School of Medicine, Washington University, 4921 Parkview Place, St. Louis, Missouri 63110, USA.

Medical Physics
|February 10, 2011
PubMed
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This study developed a dynamic multileaf collimator (DMLC) tracking algorithm for volumetric-modulated arc therapy (VMAT) to manage intrafraction motion. The algorithm accurately delivers VMAT to moving targets with minimal increases in treatment time.

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Image-Guided Therapy

Background:

  • Intrafraction motion management is crucial for effective radiation therapy.
  • Dynamic multileaf collimator (DMLC) tracking offers a promising solution for real-time motion compensation.
  • Volumetric-modulated arc therapy (VMAT) requires precise delivery, which is challenged by target motion.

Purpose of the Study:

  • To develop and evaluate a DMLC tracking algorithm for VMAT delivery.
  • To manage targets experiencing two-dimensional (2D) rigid motion in the beam's eye view.
  • To ensure accurate dose delivery while maintaining treatment plan integrity.

Main Methods:

  • Formulated VMAT delivery to moving targets as a constrained control problem.
  • Derived relationships between machine parameters and target motion.

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  • Developed an iterative search algorithm for 2D DMLC tracking and simulated delivery of five VMAT lung plans.

    • Main Results:

    • The 2D tracking algorithm successfully delivered VMAT to moving targets accurately and rapidly.
    • Average delivery time increased by only 29 seconds compared to no-tracking.
    • Average root-mean-square error in fluence maps was significantly reduced (2.1 MU) compared to no-tracking (14.8 MU) and 1D tracking (3.6 MU).

    Conclusions:

    • A locally optimal MLC tracking algorithm for VMAT delivery was proposed.
    • The algorithm aims to minimize delivery time while preserving the treatment plan.
    • The minimal increase in treatment time makes DMLC tracking for VMAT clinically attractive for treating moving tumors.