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Published on: September 16, 2019
Plasma netrin-1 is a diagnostic biomarker of human cancers
Ganesan Ramesh1, Arthur Berg, Calpurnia Jayakumar
1Department of Medicine/Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. gramesh@mcg.edu
Context:
The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues.
Objectives:
To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer.
Materials And Methods:
A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry.
Results:
Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples.
Discussion And Conclusion:
Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
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