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The beta-adrenoceptor controlling renin release.

H F Oates, L M Stoker, J C Monaghan

    Archives Internationales De Pharmacodynamie Et De Therapie
    |August 1, 1978
    PubMed
    Summary

    Beta-blockers like atenolol suppress plasma renin activity (PRA) by blocking beta1-adrenoceptors. This study suggests beta1-adrenoceptors, not beta2, mediate renin release, impacting cardiovascular research.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Endocrinology

    Background:

    • Plasma renin activity (PRA) is a key regulator of blood pressure.
    • Beta-adrenoceptors play a role in regulating renin release.
    • The specific subtype of beta-adrenoceptor involved in renin release is not fully elucidated.

    Purpose of the Study:

    • To investigate the role of beta1- and beta2-adrenoceptors in the suppression of plasma renin activity (PRA) by beta-adrenoceptor antagonists.
    • To determine whether beta1- or beta2-adrenoceptor blockade is primarily responsible for inhibiting renin release.

    Main Methods:

    • Intravenous administration of beta-adrenoceptor antagonists (atenolol, metoprolol, propranolol, practolol, butoxamine) to anesthetized rats.
    • Doses were selected to achieve equal beta1- or beta2-adrenoceptor blocking effects.
    • Measurement of plasma renin activity (PRA) following drug administration.

    Main Results:

    • Comparable suppression of PRA by atenolol, metoprolol, and propranolol at equipotent beta1-adrenoceptor blocking doses.
    • Atenolol and metoprolol suppressed PRA at equipotent beta2-adrenoceptor blocking doses, while propranolol and butoxamine did not.
    • Practolol, a selective beta1-antagonist with intrinsic sympathomimetic activity, showed less PRA suppression.

    Conclusions:

    • The findings do not support a beta2-adrenoceptor-mediated mechanism for adrenergic release of renin.
    • Results are consistent with a beta1-adrenoceptor-mediated mechanism involved in the regulation of plasma renin activity.
    • This research clarifies the specific adrenoceptor subtype involved in renin release, with implications for antihypertensive drug development.

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