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Updated: May 7, 2026

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
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Immunoadsorption (IAS) for systemic lupus erythematosus

G H Stummvoll

    Lupus
    |February 10, 2011
    PubMed

    Immunoadsorption (IAS) is used as a rescue therapy in severely ill SLE patients who are refractory to conventional therapies. This extracorporeal method aims at the rapid and extensive removal of pathogenic immunocomplexes (ICs) and (auto-)antibodies (Abs). Although past data have shown short- to mid-term efficacy and biocompatibility of IAS in (renal) SLE, it is still an experimental and rather expensive procedure - and evidence from randomized controlled trials (RCTs) is lacking. Nevertheless, IAS is successfully used in life-threatening situations because of its fast mode of action and its acceptable safety profile.

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