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Simultaneous amniotic membrane patch in high-risk keratoplasty.

Berthold Seitz1, Sujata Das, Renate Sauer

  • 1Department of Ophthalmology, University of Saarland, Germany. berthold.seitz@uks.eu

Cornea
|February 10, 2011
PubMed
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Simultaneous amniotic membrane transplantation with high-risk keratoplasty improved corneal graft clarity and epithelial healing in most patients. This combined approach offers a promising solution for eyes facing challenges in corneal wound repair.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Corneal Surgery

Background:

  • High-risk keratoplasty presents challenges in corneal graft survival and epithelial healing.
  • Amniotic membrane transplantation is explored as an adjunct to promote ocular surface recovery.

Purpose of the Study:

  • To evaluate the short- and intermediate-term outcomes of combining amniotic membrane transplantation with penetrating keratoplasty.
  • To assess the impact on corneal graft clarity and epithelial defect closure in high-risk cases.

Main Methods:

  • A prospective study involving 16 eyes undergoing simultaneous amniotic membrane patch and penetrating keratoplasty.
  • Use of soft contact lenses post-operatively in 13 eyes.
  • Systemic immunosuppressive medication administered to 5 patients.

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Main Results:

  • Complete epithelial closure was achieved in 15 out of 16 eyes within 10 days.
  • 13 out of 16 corneal grafts remained clear during an 18-month follow-up.
  • Recurrence of epithelial defects occurred in 3 eyes between 3-6 months post-transplantation.

Conclusions:

  • Simultaneous amniotic membrane transplantation and penetrating keratoplasty can enhance corneal graft prognosis.
  • This combined procedure shows potential benefits for patients with compromised epithelial healing capacity.