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Regulation of epidermal growth factor receptor expression and activation: a brief review

J D Haley1

  • 1Department of Cancer Therapeutics, Oncogene Science Inc., Manhasset, NY 11030.

Symposia of the Society for Experimental Biology
|January 1, 1990
PubMed

Insights

The epidermal growth factor receptor (EGFR) is vital for cell signaling and development. This review covers EGFR

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • The epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase.
  • EGFR is crucial for cellular signaling in embryonic development and adult tissues.
  • It regulates gene expression, ion flux, and mitogenesis through substrate phosphorylation.

Purpose of the Study:

  • To review structure-function relationships of the EGF receptor proto-oncogene.
  • To examine data on EGFR overexpression in human tumors.
  • To highlight EGFR as a model system for signal transduction research.

Main Methods:

  • Literature review of structure-function relationships.
  • Analysis of data on EGFR overexpression.
  • Focus on tyrosine kinase signaling pathways.

Main Results:

  • EGFR's role in cellular transformation is linked to its structure-function.
  • Overexpression of EGFR is observed in various human tumors.
  • EGFR's signaling mechanisms provide insights into cancer development.

Conclusions:

  • Understanding EGFR structure-function is key to comprehending cellular transformation.
  • EGFR overexpression is a significant factor in human oncogenesis.
  • EGFR remains a valuable model for signal transduction and cancer research.

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