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Published on: January 29, 2016
Association between change in physical activity and short-term disability progression in multiple sclerosis
Robert W Motl1, Edward McAuley
1Department of Kinesiology and Community Health, University of Illinois, 350 Freer Hall, Urbana, IL 61801, USA. robmotl@uiuc.edu
Objective:
This study examined change in physical activity as a behavioral correlate of short-term disability progression in persons with multiple sclerosis over a 6-month period.
Design:
Panel design.
Subjects:
The sample included 292 persons with multiple sclerosis.
Methods:
Participants wore an accelerometer for 7 days as a measure of physical activity and then provided demographics and clinical information and completed the Patient Determined Disease Steps scale as a measure of disability. After a 6-month period, participants provided information about the occurrence of a relapse in the previous 6 months and again wore an accelerometer for 7 days and completed the Patient Determined Disease Steps scale.
Results:
Panel analysis indicated associations between baseline physical activity and disability (path coefficient= -0.41, p<0.001) and 6-month change in physical activity and disability progression (path coefficient= -0.09, p=0.025).
Conclusion:
Such findings provide preliminary support for a reduction in physical activity as a behavioral correlate, but not necessarily cause, of short-term disability progression in persons with multiple sclerosis.
