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Updated: Jun 4, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
[Female patient with Sjoegren's syndrome and cardiolipin antibodies]
S Vilardi1, K Muth, M Uppenkamp
1Medizinische Klinik A, Klinikum der Stadt Ludwigshafen gGmbH, Bremserstrasse 79, Ludwigshafen, Germany.
Insights
False-positive syphilis tests can occur with autoimmune diseases. This case highlights a patient with Sjogren
Area of Science:
- Rheumatology
- Infectious Diseases
- Neurology
Background:
- Antiphospholipid syndrome and Sjogren's syndrome are autoimmune disorders.
- Cardiolipin antibodies are associated with antiphospholipid syndrome and can cause false-positive syphilis tests.
- Syphilis (lues) is a bacterial infection with a distinct serological profile.
Abstract:
Cross-reactions with cardiolipin antibodies and serological lues tests are common. We examined a 37 year old patient with neurological symptoms and signs of Sjoegren's syndrome and secondary antiphospholipid syndrome. But the lues screening test was also positive and the serological tests following approved the lues infection. When an autoimmune disease is diagnosed with the presence of cardiolipin antibodies we recommend also testing for treponema pallidum as a possible disease.
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