Related Experiment Video
Updated: Jun 4, 2026
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Influence of glycemic control on tympanic membrane healing in diabetic rats
Holger Kaftan1, Lars Reuther, Bärbel Miehe
1Department of Otorhinolaryngology and Head and Neck Surgery, Ernst Moritz Arndt University, Greifswald, Germany. holger.kaftan@uni-greifswald.de
Objectives/Hypothesis:
It is generally assumed that glycemic control in diabetic patients is important in optimizing wound healing. The goal of this study was to examine tympanic membrane (TM) wound healing in spontaneously diabetic rats depending on the diabetic metabolic state compared to nondiabetic control animals.
Study Design:
Prospective controlled study in experimental animals.
Methods:
Right-sided myringotomy was performed in 20 normoglycemic rats, 17 well-compensated, and 23 poorly compensated diabetic rats. TMs were observed for a total of 3 weeks. Effect of diabetic metabolic state on the healing of the TMs was evaluated by closure rates and histology.
Results:
Diabetic rats showed a significant delay in TM wound healing compared to the control group, but there were no significant differences between both diabetes groups.
Conclusions:
Glycemic control does not influence TM wound repair in an animal model of type 1 diabetes.