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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...

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Related Experiment Video

Updated: Jun 4, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs in cardiomyocyte development.

Andrea P Malizia1, Da-Zhi Wang

  • 1Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
|February 10, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression in cardiac muscle. Specific miRNAs, called myomiRs, are key to cardiomyocyte development and offer potential cardiovascular disease therapies.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression.
  • Cardiac muscle development involves specific genes and signaling pathways.
  • The role of miRNAs in cardiac development is a recent area of investigation.

Purpose of the Study:

  • To explore the role of miRNAs in cardiac muscle gene regulation.
  • To identify muscle-specific miRNAs (myomiRs) involved in cardiomyocyte development.
  • To understand the regulatory networks of myomiRs in cardiac tissue.

Main Methods:

  • Analysis of tissue-specific miRNA expression in cardiac muscle.
  • Identification of myomiRs, including miR-1, miR-133, miR-206, and miR-208.
  • Investigating post-transcriptional gene regulation by myomiRs.

Main Results:

  • A subset of miRNAs are specifically or highly expressed in cardiac muscle.
  • These muscle-specific miRNAs, termed myomiRs, are involved in regulating cardiac development.
  • MyomiRs represent a novel layer of gene expression control in cardiomyocytes.

Conclusions:

  • MyomiRs are essential components of cardiac muscle gene regulation.
  • Understanding myomiR networks provides insights into cardiomyocyte development.
  • MyomiRs present potential therapeutic targets for cardiovascular diseases.