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Acute Pyelonephritis I: Introduction

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...

Acute Pyelonephritis II: Diagnostic Studies and Management

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...

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Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

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Published on: April 22, 2011

Bone morphogenetic protein-7 expression in human pyelonephritis.

Josip Spanjol¹, Gordana Djordjevic, Dean Markić

¹Department of Urology, University Hospital of Rijeka, Rijeka, Croatia. jspanjol@vip.hr

Collegium Antropologicum

|February 10, 2011

Summary

This summary is machine-generated.

Bone morphogenetic protein 7 (BMP-7) shows protective effects in kidney disease. Higher BMP-7 expression in acute pyelonephritis suggests a role in preventing renal fibrosis and damage.

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Area of Science:

Nephrology
Molecular Biology
Pathology

Background:

Bone morphogenetic protein 7 (BMP-7) is a TGF-beta superfamily member involved in tissue development and repair.
Experimental studies indicate BMP-7 possesses protective properties against fibrotic processes.
Pyelonephritis is characterized by tubulointerstitial changes that can lead to renal fibrosis and function loss.

Purpose of the Study:

To investigate the expression of BMP-7 in human kidneys affected by acute and chronic pyelonephritis.
To determine the correlation between BMP-7 expression and histopathological findings like fibrosis and tubular atrophy.

Main Methods:

Histopathological analysis of renal tissue using hematoxylin and eosin staining for diagnosis.
Immunohistochemical staining to assess BMP-7 expression in tubular areas.
Study included 7 patients with acute pyelonephritis and 7 with chronic pyelonephritis.

Main Results:

BMP-7 expression was detected in the tubular compartment of pyelonephritic kidneys.
BMP-7 expression was significantly stronger in acute pyelonephritis compared to chronic pyelonephritis.
Tubular BMP-7 expression demonstrated a negative correlation with renal fibrosis and tubular atrophy.

Conclusions:

BMP-7 expression is present in pyelonephritis, with higher levels in the acute phase.
The findings suggest BMP-7 plays a crucial protective role in renal inflammatory diseases.
BMP-7 may prevent progressive renal damage and fibrosis in conditions like pyelonephritis.