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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Postinfectious glomerulonephritis and Epstein-barr virus co-infection
Mirna Subat-Dezulović1, Nada Sindifić Dessardo, Matko Dezulović
1Clinical Hospital Center, Children's Hospital Kantrida , Department of Pediatric Nephrology and Dialysis, Rijeka, Croatia. sindin2@net.hr
Collegium Antropologicum
|February 10, 2011
Summary
This study reports the first case of postinfectious glomerulonephritis (PIGN) co-infected with both Streptococcus and Epstein-Barr virus (EBV). EBV DNA was found in kidney tissue, suggesting EBV may contribute to PIGN more often than previously thought.
Area of Science:
- Nephrology
- Virology
- Immunology
Background:
- Postinfectious glomerulonephritis (PIGN) is typically caused by Streptococcus.
- Epstein-Barr virus (EBV) is rarely associated with acute kidney injury.
Observation:
- An 11-year-old boy presented with symptoms of infectious mononucleosis and acute glomerulonephritis.
- Clinical signs included edema, hypertension, dark urine, and reduced kidney function.
- Serology confirmed both streptococcal and acute EBV infections.
Findings:
- Renal biopsy revealed PIGN and acute interstitial nephritis, consistent with streptococcal infection.
- Polymerase chain reaction (PCR) detected EBV DNA in kidney tissue.
- This is the first reported case of PIGN with confirmed co-infection of Streptococcus and acute EBV.
Implications:
- The presence of EBV DNA in renal tissue suggests a dual role for EBV and Streptococcus in causing renal inflammation.
- Evaluating EBV serology in patients with mononucleosis and renal symptoms may reveal a more frequent association between EBV and PIGN.
- This case highlights the importance of considering viral etiologies in PIGN beyond typical bacterial causes.
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