Related Experiment Video
Updated: Jun 4, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
Antinociceptive activity of Premna corymbosa (Burm.f.)Rottl. & Willd
1Department of Pharmacology, Al Shifa College of Pharmacy, Poonthavanam (P.O.), Kizhattur, Perinthalmanna, Kerala State 679 325, India. karthikeyanpgt@gmail.com
Abstract:
The aim of this work was to evaluate the acute toxicity and antinociceptive activity of an ethanolic extract of Premna corymbosa in animal models. In the acute toxicity study, the ethanolic extract showed no clinical signs and mortality of the animals and was found to be safe. In the acetic acid-induced writhing model, the ethanolic extract at a dose of 200 or 400 mg kg(-1) body weight significantly (p < .01) inhibited the writhing response by 42.57% and 54.67%, respectively. In the hot plate test, the extract produced a significant (p < .01) increase in latency with 34.50% and 51.08% of protection in a dose-related manner. This study has established the analgesic properties of P. corymbosa (Burm.f.) Rottl. and Willd. The beta-sitosterol or luteolin present in the ethanolic extract may contribute the antinociceptive activity of P. corymbosa.
Related Concept Videos
Nociception
Analgesia and Pain Management
Peripherally and Centrally Acting Muscle Relaxants: A Comparison
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic drugs,...
Cholinergic Antagonists: Pharmacological Actions
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...