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Updated: Jun 4, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Risk factors and treatment of stroke at the time of recurrence
P Laloux1, F Lemonnier, J Jamart
1Department of Neurology, Institut des Neurosciences (IoNS), Mont-Godinne University Hospital, Yvoir, Belgium. patrice.laloux@uclouvain.be
Insights
Secondary stroke prevention strategies are underutilized in clinical practice. Improved implementation and patient education are crucial for reducing recurrent ischemic strokes and improving patient outcomes.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Public Health
Background:
- Recurrent ischemic strokes represent a significant clinical challenge.
- Understanding the real-world implementation of secondary prevention strategies is vital.
Purpose of the Study:
- To evaluate the adherence to recommended secondary prevention therapies for ischemic stroke in clinical practice.
- To identify gaps in the management of risk factors and treatment in patients experiencing recurrent ischemic strokes.
Main Methods:
- Prospective registration of patients admitted for recurrent ischemic stroke or transient ischemic attack (TIA).
- Etiological classification using the TOAST criteria.
- Recording of risk factors and cardiovascular treatments at recurrence.
Main Results:
- 168 patients evaluated; 61% recurred after 1 year.
- Hypertension (79%), hypercholesterolemia (43%), smoking (25%), and diabetes (22%) were common risk factors, often co-existing.
- Suboptimal control of hypertension (38%), hypercholesterolemia (42%), and diabetes (59%) was observed.
- 15% of patients were not on antithrombotic agents; only 34% with atrial fibrillation received anticoagulation (INR < 2.0 in 71%).
Conclusions:
- Current clinical practice shows significant deficiencies in implementing secondary stroke prevention strategies.
- Enhanced patient education on risk factor management, physical activity, and smoking cessation is necessary.
- Improved adherence to antithrombotic and anticoagulant therapies is critical for reducing stroke recurrence.
Abstract:
The profile of recurrent ischemic strokes has not been much investigated. The aim of this study was to evaluate how the therapeutic strategies recommended for secondary prevention after an ischemic stroke are implemented in the real world of clinical practice. All patients admitted for a recurrent ischemic stroke or TIA were prospectively registered. The etiology was determined according to the TOAST classification. The risk factors and cardiovascular treatment at the time of the recurrence were recorded. A total of 168 patients were evaluated. Most of the patients (61%) recurred after 1 year. The recurrent stroke was not associated with a particular etiological subtype. The most frequent risk factor was hypertension (79%), followed by hypercholesterolemia (43%), smoking (25%), and diabetes (22%). Most of the patients had more than 1 risk factor (84%). Hypertension was not satisfactorily controlled in 38% of patients, hypercholesterolemia in 42%, and diabetes in 59%. A significant minority of patients (15%) were not taking any antithrombotic agent despite a history of stroke or TIA. Only 34% of the cases with a known atrial fibrillation were on anticoagulant therapy and the International Normalized Ratio was < 2.0 in 71% of them. In conclusion, stroke prevention needs to be improved by better implementation of therapeutic strategies in clinical practice. The patients should also be better informed about target values as well as the importance of physical activity and smoking cessation.
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