Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustained symptom relief and safety over five years following a single intra-articular injection of 2.5[%] polyacrylamide hydrogel in patients with knee osteoarthritis.

Clinical and experimental rheumatology·2026
Same author

Exploring clusters based on ultrasound-detected inflammation in patients with psoriatic arthritis: a post-hoc analysis from the ULTIMATE trial.

BMC musculoskeletal disorders·2026
Same author

Methotrexate for Osteoarthritis: What Does the Evidence Say?

Drugs & aging·2026
Same author

Three-year follow-up from a randomised controlled trial of a single intra-articular polyacrylamide hydrogel injection in subjects with knee osteoarthritis.

Clinical and experimental rheumatology·2026
Same author

A prospective, open-label, clinical investigation of a single intra-articular polyacrylamide hydrogel injection in participants with knee osteoarthritis: a 5-year extension study.

Journal of orthopaedic surgery and research·2025
Same author

Baseline loss of knee extension is associated with regional MRI progression in knee osteoarthritis: a retrospective longitudinal cohort study-data from the osteoarthritis initiative.

Rheumatology international·2025

Related Experiment Video

Updated: Jun 4, 2026

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Optimising pain control in osteoarthritis.

Claire Y J Wenham1, Philip G Conaghan

  • 1Section of Musculoskeletal Disease, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit.

The Practitioner
|February 11, 2011
PubMed
Summary

Osteoarthritis significantly impacts daily life, causing pain and limiting activities. Effective management involves addressing joint inflammation, pain, and associated psychological distress for improved quality of life.

Area of Science:

  • Rheumatology
  • Pain Management
  • Medical Imaging

Background:

  • Osteoarthritis (OA) severely affects quality of life, with 81% experiencing constant pain or functional limitations.
  • Joint pain, stiffness, and reduced activity are hallmark symptoms, often accompanied by anxiety and depression.
  • The OA process involves synovial lining and subchondral bone changes, impacting joint function.

Purpose of the Study:

  • To review current understanding and management strategies for osteoarthritis pain.
  • To highlight the role of synovitis and subchondral bone changes in OA pain.
  • To discuss pharmacological and interventional treatment options for OA.

Main Methods:

  • Literature review of osteoarthritis management, including pharmacological and interventional therapies.

More Related Videos

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Related Experiment Videos

Last Updated: Jun 4, 2026

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

  • Discussion of diagnostic imaging findings such as MRI and ultrasound in OA.
  • Analysis of treatment efficacy and safety profiles for various OA interventions.

    • Main Results:

    • Synovitis is nearly universal in painful knee OA and present in 45% of hand OA cases, suggesting it's a key target for treatments like NSAIDs.
    • Subchondral bone changes are common and linked to pain; topical NSAIDs offer short-term relief without systemic toxicity.
    • Oral NSAIDs, COX-2 inhibitors (with PPIs), opioids, and intra-articular corticosteroids are treatment options for moderate to severe pain.

    Conclusions:

    • Optimal OA pain management requires a multimodal approach, considering joint pathology and patient-specific factors.
    • Early identification and treatment of psychological comorbidities like anxiety and depression are crucial.
    • Strategic timing of analgesia, including long-acting preparations, can enhance exercise adherence and daily function.