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Partitioning of intravenous lidocaine into gastric juice
1Department of Gastroenterology, Silesian School of Medicine, Katowice, Poland.
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|September 1, 1990
Abstract:
Lidocaine concentration in gastric juice and serum, following a single bolus iv injection of lidocaine hydrochloride 1.4 mg.kg-1 was examined in 6 healthy male volunteers under basal conditions and/or after pentagastrin secretory stimulation. Lidocaine concentration found in the gastric secretion exceeded by several times that found in serum. The partitioning of iv lidocaine into stomach lumen ranged between 5.2 and 13.0% of the total lidocaine dose given.