Related Experiment Video
Updated: Aug 17, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Grey dynamic model of predicting the long-term effects of drugs and its application to pirenzepine
1Department of Pharmacology, Institute of Military Medical Sciences of Najing PLA, China.
Abstract:
In an attempt to approach the quantification of the dynamics of drug effects and the prediction of the long-term effects of drugs, a grey dynamic model was proposed and it was applied to predict the long-term effects of pirenzepine on pupils and peripheral leukocytes in dogs. The inconsiderable relative errors between the predicted and observed values suggest that the model-based equations for pupil diameter, neutrophils (%) and lymphocytes (%) which, obtained by fitting the data measured before and during initial 16 wk experiment, are acceptable for predicting the effects after 20- and 24-wk treatment with the drug.
More Related Videos
Related Concept Videos
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Pharmacodynamic Models: Overview
Pharmacodynamic Models: Linear Concentration–Effect Model
Pharmacodynamic Models: Additive and Proportional Drug Effect Model
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

