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Inflammatory and neuroendocrine biomarkers of prognosis after ischemic stroke

Mira Katan1, Mitchell S V Elkind

  • 1Stroke Division, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. mk3270@columbia.edu

Expert Review of Neurotherapeutics
|February 11, 2011
PubMed

Insights

Identifying reliable prognostic biomarkers after acute stroke is crucial for patient care. This review focuses on inflammatory and neuroendocrine markers, highlighting their potential to improve clinical decision-making and resource allocation.

Area of Science:

  • Neurology
  • Biomarkers
  • Clinical Medicine

Background:

  • Stroke is a leading cause of death and disability in the USA.
  • Accurate prognostic information is vital for optimizing stroke patient care and healthcare resource allocation.
  • Early prognostic markers can significantly aid clinical decision-making post-stroke.

Purpose of the Study:

  • To review selected inflammatory and neuroendocrine candidate biomarkers for acute stroke prognosis.
  • To assess the utility of biomarkers in improving clinical decision-making beyond standard assessments.
  • To discuss the current status and future directions of prognostic biomarker research in stroke.

Main Methods:

  • Literature review focusing on inflammatory and neuroendocrine markers.
  • Analysis of biomarker utility based on improving clinical decision-making and providing timely information.
  • Discussion of existing data and ongoing research.

Main Results:

  • Several candidate biomarkers, including inflammatory and neuroendocrine markers, have been investigated for stroke prognosis.
  • The utility of current biomarkers is defined by their ability to enhance clinical decisions and offer information beyond routine examination and imaging.
  • No single biomarker has fully achieved the aim of significantly improving clinical decision-making yet.

Conclusions:

  • Prognostic biomarkers hold promise for improving acute stroke management.
  • Further research is needed to validate and implement these markers effectively in clinical practice.
  • Selected inflammatory and neuroendocrine markers show potential for aiding in stroke prognosis and patient care optimization.

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