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Antiplatelet resistance in stroke
Mehmet Akif Topçuoglu1, Ethem Murat Arsava, Hakan Ay
1Hacettepe University Hospitals, Department of Neurology, Ankara, Turkey.
Expert Review of Neurotherapeutics
|February 11, 2011
Summary
High rates of antiplatelet resistance to aspirin and clopidogrel are common in stroke patients. Further research is needed to determine if guided antiplatelet therapy improves stroke care and reduces recurrent events.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- High prevalence of antiplatelet resistance to aspirin and clopidogrel in ischemic stroke patients.
- Inadequate antiplatelet response is linked to higher risks of recurrent ischemic vascular events.
Purpose of the Study:
- To review the clinical significance of laboratory antiplatelet resistance.
- To discuss challenges and practical issues in guiding antiplatelet therapy with platelet function tests for stroke patients.
Main Methods:
- Literature review on antiplatelet resistance prevalence and clinical impact.
- Discussion of challenges in platelet function test-guided antiplatelet treatment.
Main Results:
- Estimates suggest high rates of resistance to aspirin and clopidogrel.
- Correlation between inadequate antiplatelet responsiveness and increased risk of recurrent vascular events.
Conclusions:
- Large-scale trials are needed to validate platelet-function test-guided antiplatelet treatment for stroke.
- Management strategies for patients with aspirin and/or clopidogrel resistance require further investigation.
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