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Related Experiment Videos

First trimester chorionic villus sampling for DNA analysis.

A Bolodár1, K Horváth, M Németi

  • 1Department of Obstetrics and Gynecology, University Medical School, Debrecen, Hungary.

Acta Universitatis Carolinae. Medica
|January 1, 1990
PubMed
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Early prenatal diagnosis of cystic fibrosis (CF) is now possible using chorionic villus sampling (CVS) in the first trimester. This study found that sample quality and quantity were consistent across six different CVS devices in 336 women.

Area of Science:

  • Medical Genetics
  • Prenatal Diagnostics

Background:

  • Cystic Fibrosis (CF) diagnosis can be achieved prenatally.
  • DNA markers on chromosome 7 facilitate linked analysis for CF.
  • First-trimester prenatal diagnosis is achievable via Chorionic Villus Sampling (CVS).

Purpose of the Study:

  • To evaluate the feasibility and consistency of first-trimester prenatal diagnosis of Cystic Fibrosis (CF).
  • To assess the impact of different sampling devices on chorionic villus tissue acquisition.

Main Methods:

  • Conducted prenatal diagnosis for Cystic Fibrosis (CF) in 336 pregnant women.
  • Utilized Chorionic Villus Sampling (CVS) between 8-12 weeks of gestation.
  • Employed six distinct types of sampling devices for chorionic tissue retrieval.

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Main Results:

  • Successfully performed first-trimester prenatal diagnosis in 336 cases.
  • Acquired chorionic tissue samples of consistent quantity and quality.
  • Demonstrated that sample characteristics were independent of the specific CVS device used.

Conclusions:

  • Early prenatal diagnosis of Cystic Fibrosis (CF) is reliable using first-trimester Chorionic Villus Sampling (CVS).
  • The choice of sampling device does not significantly affect the quality or quantity of chorionic villus tissue obtained.