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Updated: Jun 4, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in
C Abi Khalil1, K Mohammedi, R Aubert
1Service de Diabétologie, Endocrinologie et Nutrition, Hôpital Bichat, Assistance publique des Hôpitaux de Paris, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
Introduction:
As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN.
Patients And Methods:
A total of 15 T1D and 48 T2D patients with HbA(1c) greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6 months after insulin treatment.
Results:
While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study.
Conclusion:
Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.
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