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Related Experiment Video

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Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
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A circuit model for saccadic suppression in the superior colliculus.

Penphimon Phongphanphanee1, Fengxia Mizuno, Psyche H Lee

  • 1National Institute for Physiological Sciences, Okazaki 444-8585, Japan.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 11, 2011
PubMed
Summary

Visual activity in the superior colliculus (SC) is attenuated during saccades. This study shows that premotor neurons in the intermediate SC layer inhibit superficial SC layers, suppressing visual responses during saccades.

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Area of Science:

  • Neuroscience
  • Visual processing
  • Motor control

Background:

  • Saccades, rapid eye movements, cause visual blurring.
  • The superior colliculus (SC) plays a role in visual processing and eye movements.
  • A model proposed that premotor cells in the SC's intermediate layer inhibit superficial layers to suppress visual activity during saccades.

Purpose of the Study:

  • To test the hypothesis that premotor neurons in the SC's intermediate layer inhibit superficial SC layers.
  • To investigate the neural pathway responsible for saccade-induced visual attenuation in the SC.

Main Methods:

  • Whole-cell patch-clamp recordings were performed in rat and GAD67-GFP knock-in mouse brain slices.
  • Antidromic electrical stimulation of premotor cells in the stratum griseum intermedium (SGI) was used.
  • Excitatory postsynaptic potentials (EPSCs) and inhibitory postsynaptic potentials (IPSCs) were recorded in SC neurons.

Main Results:

  • Antidromic stimulation of SGI premotor cells evoked monosynaptic EPSCs in SGI GABAergic neurons projecting to superficial layers (SLs).
  • IPSCs were evoked in SL neurons, indicating inhibition mediated by GABAergic neurons.
  • These findings support the proposed inhibitory pathway from premotor to superficial SC layers.

Conclusions:

  • Collaterals of premotor neuron axons excite GABAergic neurons in the intermediate SC layer.
  • These GABAergic neurons then inhibit visuosensory cells in the superficial SC layers.
  • This pathway contributes to the suppression of visual activity during saccades, reducing blur and preventing unwanted saccades.