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Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
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PICK1 loss of function occludes homeostatic synaptic scaling.

Victor Anggono1, Roger L Clem, Richard L Huganir

  • 1Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 11, 2011
PubMed
Summary

This study reveals that PICK1 protein is crucial for synaptic scaling during neuronal inactivity. Its absence impairs the trafficking of AMPA receptors (AMPARs), affecting synaptic strength regulation.

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