Related Experiment Video
Updated: Jun 4, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Diagnosis and management of inflammatory bowel disease
Abstract:
The onset of ulcerative colitis is characterized by diarrhea and bleeding, while granulomatous ileocolitis may be similar or more obscure with abdominal pain, bowel obstruction, loss of weight, iritis, arthritis or hypoalbuminemia. The diagnosis in ulcerative colitis is made by sigmoidoscopy and barium enema, while small bowel follow through is necessary in ileocolitis. Ulcerative colitis is treated by adrenocorticosteroids as retention enemas when limited to the left colon, intravenous ACTH or steroids in severe pancolitis and oral steroids in others. Sulphasalazine is used in addition to steroids in acute cases and as maintenance to prevent exacerbations. Proctocolectomy is indicated in those with severe disease with complications not responding to steroids. The treatment of Crohn's disease is similar but complicated by small bowel involvement and recurrence after surgery.
Related Concept Videos
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory Bowel Disease I: Introduction
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
